Microglia as Dynamic Cellular Mediators of Brain Function
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinases as mediators of reproductive function.
The organs of the adult reproductive system can undergo extensive remodelling, experiencing rapid changes in tissue mass and function. Much of this matrix remodelling is attributed to the action of matrix metalloproteinases. Matrix metalloproteinase family members are expressed in a highly-regulated manner in many reproductive processes, including menstruation, ovulation, implantation, and uter...
متن کاملP108: Microglia in Traumatic Brain Injury
Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...
متن کاملP27: Brain Network as a Pivotal Part in Intelligence Function
Neuroimaging findings have proposed that some brain regions including the precuneus, posterior cingulate, and medial prefrontal cortex play an essential role of a structural core in the brain. Network organization endures rapid alterations in development with changes in axonal synaptic connectivity, white matter volume, and the thickness of corresponding cortical regions. Structural maturation ...
متن کاملReceptor protein tyrosine phosphatases as mediators of cellular adhesion.
Receptor protein tyrosine phosphatases (RPTPs) are structurally characterized by the diversity of their extracellular domains (ECDs). These domains display Ig-like, fibronectin type III (FNIII), MAM (meprin, A5, PTPmu), and carbonic anhydrase (CAH) motifs that resemble those present in many cell adhesion molecules (CAMs). However, in contrast to most CAMs, RPTPs also contain an intracellular do...
متن کاملMicroglia as a stem cell
Microglia is considered the only cell population of mesodermal origin, which comprises 10% of the cells in brain parenchyma. Recent neural stem cell (NSC) studies demonstrate that the brain has regenerative potential. NSCs do not give rise to microglial cells, however indicating that NSCs alone cannot complete the regenetion of the brain. Although the role of microglia is not fully understood, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2019
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2019.08.013